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| Presented
by: |
Professor Aleksandar Janca External Examiner of the Hong Kong College of Psychiatrists |
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| Date: |
31 May 2012 |
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| Time: |
16:00 |
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| Venue: |
J2 Seminar Room, 2/F Block J, QMH |
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| About the speaker: |
Dr Aleksandar Janca is the Winthrop Professor of Psychiatry and Head of School of Psychiatry and Clinical Neurosciences at the University of Western Australia in Perth. He also works as a Consultant Psychiatrist at Royal Perth Hospital and is Director of the WHO Collaborating Centre in Perth. Dr Janca started his research career in 1987 as a Fulbright Scholar at the Department of Psychiatry, Washington University School of Medicine in St Louis, Missouri. From 1991 to 1997 he worked as a Medical Officer at WHO Headquarters in Geneva and was responsible for coordination of a number of international projects in the areas of psychiatric nosology, psychiatric epidemiology and transcultural psychiatry. Dr Janca has a particular interest in the development and evaluation of novel psychiatric concepts, assessment instruments in psychiatry and Aboriginal mental health. He has published more then 200 scientific papers, book chapters and books. |
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| Presented
by: |
Professor Sander L. Gilman
Distinguished Professor of the Liberal Arts and Sciences;
Professor of Psychiatry, Emory University |
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| Date: |
15 March 2012 |
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| Time: |
16:00 |
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| Venue: |
Seminar Room 3, G/F, Laboratory Block, LKS Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, HK
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| Abstract:
|
“Self-harm” is now proposed as a full-fledged diagnostic category for DSM-V. The existing literature of the topic posits that it is a universal psychiatric category and that examples of self-harm can be found in the earliest written records. This is de facto part of the underlying argument for its inclusion in DSM-V. But how old is self-harm and indeed what defines “self-harm” historically and culturally? This vitally important category demands such an examination before it is assumed to be a universally valid diagnostic category. |
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| About the speaker: |
Sander L. Gilman is a distinguished professor of the Liberal Arts and Sciences as well as Professor of Psychiatry at Emory University. A cultural and literary historian, he is the author or editor of over eighty books. His Obesity: The Biography appeared with Oxford University Press in 2010; his most recent edited volume, Wagner and Cinema (with Jeongwon Joe) was published in that same year. He is the author of the basic study of the visual stereotyping of the mentally ill, Seeing the Insane, published by John Wiley and Sons in 1982 (reprinted: 1996) as well as the standard study of Jewish Self-Hatred, the title of his Johns Hopkins University Press monograph of 1986. For twenty-five years he was a member of the humanities and medical faculties at Cornell University where he held the Goldwin Smith Professorship of Humane Studies. For six years he held the Henry R. Luce Distinguished Service Professorship of the Liberal Arts in Human Biology at the University of Chicago and for four years was a distinguished professor of the Liberal Arts and Medicine and creator of the Humanities Laboratory at the University of Illinois at Chicago. During 1990-1991 he served as the Visiting Historical Scholar at the National Library of Medicine, Bethesda, MD; 1996-1997 as a fellow of the Center for Advanced Study in the Behavioral Sciences, Stanford, CA; 2000-2001 as a Berlin prize fellow at the American Academy in Berlin; 2004-5 as the Weidenfeld Visiting Professor of European Comparative Literature at Oxford University; 2007 to the present as Professor at the Institute in the Humanities, Birkbeck College; 2010 to the present as a Visiting Research Professor at The University of Hong Kong. He has been a visiting professor at numerous universities in North America, South Africa, The United Kingdom, Germany, Israel, China, and New Zealand. He was president of the Modern Language Association in 1995. He has been awarded a Doctor of Laws (honoris causa) at the University of Toronto in 1997, elected an honorary professor of the Free University in Berlin (2000), and an honorary member of the American Psychoanalytic Association (2007). |
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| Presented
by: |
Professor Thomas Fahy, Professor of Forensic Mental Health/ Clinical Director SLAM Forensic Services, King’s College London. |
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| Date: |
8 March 2012 |
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| Time: |
15:45 - 16:45 |
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| Venue: |
J2 Seminar Room, 2/F, Block J, QMH. |
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| Presented
by: |
Prof Michael Qiwei ZHANG, Visiting Research Professor |
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| Date: |
22 December 2011 |
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| Time: |
11:00a.m. - 11:45a.m. |
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| Venue: |
Seminar Room 4, G/F, Room LG-S4, Laboratory Block,
Faculty of Medicine Building, 21 Sassoon Road,
Pokfulam, Hong Kong.
|
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| Presented
by: |
Mr. Xueya ZHOU,
MOE Key Lab of Bioinformatics
Dept of Automation
Tsinghua University, China
|
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| Date: |
22 December 2011 |
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| Time: |
11:45a.m. - 12:30p.m. |
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| Venue: |
Seminar Room 4, G/F, Room LG-S4, Laboratory Block,
Faculty of Medicine Building, 21 Sassoon Road,
Pokfulam, Hong Kong. |
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| Presented
by: |
Professor Robert Miller,
Honorary Fellow,
Department of Psychological Medicine
Otago University, Wellington
|
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| Date: |
17 October 2011 |
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| Time: |
18:30 - 19:30 |
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| Venue: |
MWT6, Meng Wah Complex, The University of Hong Kong |
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| Presented
by: |
Dr. Deborah Ann Mountain, Consultant in Intensive Psychiatric Care Unit and Rehabilitation, Royal Edinburgh Hospital |
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| Date: |
22 September 2011 |
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| Time: |
14:30 - 15:30 |
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| Venue: |
J2 Seminar Room, Queen Mary Hospital |
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| Presented
by: |
Ying Kit Ho, BScn(Hon),RN, Registered Nurse (Psychiatryc), Department of Psychiatry, Pamela Youde Nethersole Eastern Hospital
Mike TP Wong, PhD, Clinical Psychologist, Psychogeriatrics, Kwai Chung Hospital Neuropsychology Laboratory, Department of Psychology, HKU
Andrew CK Law, MD, PhD, FRCPC, Clinical Assistant Professor, Department of Psychiatry, HKU |
| |
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| Date: |
10 June 2011 |
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| Time: |
14:10 pm |
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| Venue: |
William MW Mong Block, Lecture Theatre I |
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| Presented
by: |
Dr Jordana T Bell
Sir Henry Wellcome Postdoctoral Fellow,
Wellcome Trust Centre for Human Genetics,
University of Oxford
and
Honorary Lecturer,
Department of Twin Research and Genetic Epidemiology,
King's College London |
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| Date: |
30 May 2011 |
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| Time: |
11:00 am |
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| Venue: |
Seminar Room 4, G/F, Laboratory Block, LKS Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong |
| |
| Presented
by: |
Prof Michael Zhang,
Tsinghua University / University of Texas, Dallas / Cold Spring Harbor Laboratory
- A Novel Baysian Change-Point (BCP) Model for Better ChlP-Seq Data Analyses
Prof Jin Gu,
Tsinghua University
- Nanno: an Integrative Network-Based Annotator for Gene Functions, Signaling and Regulations
Mr Xueya Zhou,
Tsinghua University
- Hole Genome Association Studies (GWAS) based on Copy Number Variations (CNVs)
Dr Kai Ye,
Leiden University Medical Center
-
From Next-Gen Sequence Data to Personal Genome |
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| Date: |
25 May 2011 |
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| Time: |
14:30-17:45 |
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| Venue: |
Seminar Room 3,
G/F, Laboratory Block,
LKS Faculty of Medicine Building,
21 Sassoon Road, Pokfulam, H.K.
|
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| Presented
by: |
Dr. Kai Ye
Assistant Professor, Molecular Epidemiology, Medical Statistics & Bioinformatics, Leiden University Medical Center, The Netherlands |
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| Date: |
29 Apr 2011 |
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| Time: |
09:00-10:00 |
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| Venue: |
Seminar Room 6, LG1/F, Laboratory Block, LKS Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong
|
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| Presented
by: |
Prof. Sander L Gilman
Distinguished Professor of the Liberal Arts and Sciences;
Professor of Psychiatry, Emory University
Visiting Research Professor of European Studies, The University of Hong Kong |
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| Date: |
17 Feb 2011 |
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| Time: |
16:30-18:00 |
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| Venue: |
Exhibition Area, Li Ka Shing Faculty of Medicine The University of Hong Kong, Sassoon Road |
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| Abstract: |
How is pain to be assessed? Can pain be measured? Who judges pain? Is pain a mental or a physical phenomenon? Or are there any ways of distinguishing the causes or location or nature of pain?
Pain is one of the most difficult categories in medicine. Hippocrates wrestled with its meanings but only after the 18th century does the question of its "nature" become a means by which the complex inner relationship of the body and the mind are explored. In the 21st century the question of "seeing pain," one which Greek medicine thought it had answered, has reappeared as a litmus test for the very nature of the medical project. The history of seeing pain will be examined with an eye towards the claims and pitfalls of diagnosis in medicine, including in psychiatry.
|
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| Date: |
21 Jan 2011
22 Jan 2011 |
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| Time: |
9:00-17:00 |
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| Venue: |
Lecture Theatre 2, G/F, Cheung Kung Hai Conference Centre, William M.W. Mong Block, Li Ka Shing Faculty of Medicine, HKU |
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| Presented
by: |
Prof. Jurg Ott Professor Emeritus, Rockefeller University Professor, Beijing Institute of Genomics CAS |
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| Date: |
15 Dec 2010 |
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| Time: |
15:30-16:30 |
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| Venue: |
Seminar Room 1, G/F, Laboratory Block, LKS Faculty of Medicine Building, 21 Sassoon road, Pokfulam, Hong Kong |
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| Abstract: |
Various methods have been developed to deal with the potentially deleterious effects of population heterogeneity (admixture) in human case-control association studies. I will be discussing a new approach, which systematically removes extreme individuals (outliers) rather than keeping all individuals and analyzing the total dataset under an appropriate model of heterogeneity. Our method works under the assumption that admixture is due to only a small number of outlying individuals. I will demonstrate the approach on a dataset on Parkinson disease. |
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| Presented
by: |
Prof. Michael Q Zhang
Visiting Research Professor, The University of Hong Kong
Cecil H and Ida Green Distinguished Chair of Systems Biology Science Director, Center for System Biology, Department of Molecular and Cell Biology, The University of Texax at Dallas |
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| Date: |
6 Dec 2010 (Mon) |
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| Time: |
15:00-16:00 |
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| Venue: |
Seminar Room 4, G/F, Laboratory Block, LKS Faculty of Medicine Building, 21 Sassoon road, Pokfulam, Hong Kong |
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| Presented
by: |
Dr. Kevin Davies, PhD Chief Editor; Bio-IT World; Founding Editor; Nature Genetics |
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| Date: |
18 Nov 2010 |
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| Time: |
16:30 |
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| Venue: |
Seminar Room 3, G/F, Laboratory Block, LKS Faculty of Medicine Building, 21 Sassoon road, Pokfulam, Hong Kong |
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| Abstract: |
Advances in next-generation sequencing have brought us to the brink of the $1000 genome. In 2007, Jim Watson was presented with his digital genome for a cost of about $1 million. Today, the public can receive a full personal genome sequence for less than $20,000. Hundreds of whole human genomes have been sequenced in the past 12 months; many of these studies have identified disease genes and, in some cases, shaped individual medical decisions. Meanwhile, tens of thousands of people have learned about their own genetic predispositions through the services of consumer genomics companies such as 23andMe, occasionally with dramatic results. But these technological advances beg the question: how will our healthcare system integrate and deliver on the promise of genomic medicine? |
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| Presented
by: |
Mr Jorit Dekker (M.Sc.) Application Manager, Noldus Information Technology Ltd. |
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| Chaired
By: |
Dr GM Mcalonan, Assistant Professor |
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| Date: |
5 Nov 2010 |
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| Time: |
11:00-12:00 |
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| Venue: |
Mrs Chen Yang Foo Oi Telemedicine Centre
2/F, William M.W. Mong Block LKS Faculty of Medicine Building |
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| Abstract: |
This seminar will give an overview of various software and hardware tools which can help you improve the quality and quantity of the data gathered from your animals. Tools range from computer-aided manual scoring to completely automated test. Applications include (but are not limited to); zebrafish research, standard behavioral tests (open field, watermaze, NOR, Social interaction etc.), home-cage measurement, gait analysis and spinal cord injury. |
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Presented
by:
|
Dr SL Tsui, Consultant Anaesthetist |
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| Chaired
By: |
Dr KH Lau, Associate Consultant |
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| Date: |
7 Oct 2010 |
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| Time: |
14:30-15:30 |
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| Venue: |
J2 Seminar Rm, QMH |
| |
| Date: |
11 June 2010 |
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| Time: |
14:00-17:30 |
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| Venue: |
Lecture Theatre 3, G/F, William MW Mong Block,
LKS Faculty of Medicine Building |
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Presented
by:
|
Prof. Zhenyu Xuan
Assistant Professor, Department of Molecular and Cell Biology, The University of Texas at Dallas |
Chaired
by:
|
Prof Michael Qiwei Zhang
Visiting Research Professor, Department of Psychiatry and the Strategic Research Theme on Genomics |
| Date: |
7 June 2010 |
| Time: |
2:30 p.m. -3:30 p.m. |
| Venue: |
Seminar Room 6, LG1/F, Laboratory Block,Faculty of Medicine Building, 21 Sassoon Road,Pokfulam, Hong Kong. |
| Abstract: |
The fast development of new sequencing technology has greatly facilitated the cancer research at genomics level. Currently, researchers have widely used this cost-efficient method to study the genomic variations, gene expression, protein-DNA interaction, epigenomic profiling in cancer study, which produce massive amount of data. It also raises challenges to fast and correctly analyze these data. In my presentation, I will describe how we used selective sequencing methods to study somatic mutation in mouse lung cancer model, and developed related bioinformatics methods. I will also discuss the methods to identify fusion transcripts by using RNA-seq data. |
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Presented
by:
|
Prof Allan Young, Professor of Psychiatry, LEEF Chair and Director Institute of Mental Health, Department of Psychiatry, University of British Columbia |
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| Chaired
By: |
Dr Carmen Lam, Medical Officer |
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| Date: |
3 June 2010 |
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| Time: |
14:30-15:30 |
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| Venue: |
J2 Seminar Rm, QMH |
| |
Presented
by:
|
Prof Michael Qiwei Zhang
Visiting Research Professor, Department of Psychiatry and the Strategic Research Theme on Genomics |
| Date: |
31 May 2010 |
| Time: |
12:00 noon -12:45p.m. |
| Venue: |
Seminar Room 3, G/F, Room LG-S3, Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong. |
| Abstract: |
The transcription factor Hypoxia-inducible factor 1 (HIF-1) plays a central role in the transcriptional response to oxygen flux. To gain insight into the molecular pathways regulated by HIF-1, it is essential to identify the downstream-target genes. We report here a strategy to identify HIF-1-target genes based on an integrative genomic approach combining computational strategies and experimental validation. To identify HIF-1-target genes
microarrays data sets were used to rank genes based on their differential response to hypoxia.
The proximal promoters of these genes were then analyzed for the presence of conserved HIF-1- -binding sites. Genes were scored and ranked based on their response to hypoxia and their HIFbinding site score. Using this strategy we recovered 41% of the previously confirmed HIF-1-target genes that responded to hypoxia in the microarrays and provide a catalogue of predicted HIF-1 targets. We present experimental validation for ANKRD37
as a novel HIF-1-target gene. Together these analyses demonstrate the potential to recover novel HIF-1-target genes and the discovery of mammalian- regulatory elements operative in the context of microarray data sets. |
| |
Presented
by:
|
Prof. Rui Jiang, Associate Professor
MOE Key Lab of Bioinformatics, Department of Automation, Tsing Hua University |
| Date: |
31 May 2010 |
| Time: |
12:45 p.m. - 1:30 p.m. |
| Venue: |
Seminar Room 3, G/F, Room LG-S3, Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong. |
| Abstract: |
The identification of genes underlying human inherited
diseases remains a great challenge in computational system biology.
Based on the assumption that diseases sharing similar clinic traits
are caused by genes with functional similarity, we have previously
proposed a simple linear regression model to prioritize disease genes
with the use of protein-protein interaction networks. In this work,
this model is extended to integrate multiple data sources. More than
10 heterogeneous data sources (protein-protein interaction networks,
sequence similarity, protein domain annotation, pathway annotation, GO
annotation, gene expression, transcription factor binding sites, miRNA
targets, etc.) are used to measure similarities between genes, and
Fisher's combined probability test method is adopted to integrate
these data sources. The effectiveness of this data fusion approach is
demonstrated using a large scale leave-one-out cross-validation
procedure. |
| |
Presented
by:
|
Prof. Moussa B.H. Youdim, PhD, Distinguished Chair Professor, Dept. of Applied Biology & Chemical Technology, Institute of Modern Chinese Medicine (Polytechnic University) and Dept. of Anatomy (HKU) |
| |
|
| Chaired
By: |
Dr. Eileena Chui, Associate Consultant |
| |
|
| Date: |
7 January 2010 |
| |
|
| Time: |
14:30-15:30 |
| |
|
| Venue: |
J2 Seminar Rm, QMH |
Presented
by:
|
Prof Michael Qiwei Zhang
Visiting Research Professor, Department of Psychiatry and the Strategic Research Theme on Genomics |
| Date: |
14 December 2009 |
| Time: |
14:30-15:15 |
| Venue: |
Seminar Room 1, G/F, Room LG-S1, Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong. |
| Abstract: |
The precise regulation of many alternative splicing (AS) events by specific splicing factors is essential to determine tissue types and developmental stages. However, the molecular basis of tissue-specific AS regulation and the properties of splicing regulatory networks (SRNs) are poorly understood. Here we comprehensively predict the targets of the brain- and muscle-specific splicing factor Fox-1 (A2BP1) and its paralog Fox-2 (RBM9) and systematically define the corresponding SRNs genome-wide. Fox-1/2 are conserved from worm to human, and specifically recognize the RNA element UGCAUG. We integrate Fox-1/2-binding specificity with phylogenetic conservation, splicing microarray data, and additional computational and experimental characterization. We predict thousands of Fox-1/2 targets with conserved binding sites, at a false discovery rate (FDR) of ?24%, including many validated experimentally, suggesting a surprisingly extensive SRN. The preferred position of the binding sites differs according to AS pattern, and determines either activation or repression of exon recognition by Fox-1/2. Many predicted targets are important for neuromuscular functions, and have been implicated in several genetic diseases. We also identified instances of binding site creation or loss in different vertebrate lineages and human populations, which likely reflect fine-tuning of gene expression regulation during evolution. |
Presented
by:
|
Dr. Xiaowo Wang, Tsing Hua University |
| Date: |
14 December 2009 |
| Time: |
15:25-16:10 |
| Venue: |
Seminar Room 1, G/F, Room LG-S1, Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong. |
| Abstract: |
Computational prediction of human gene promoters from genomic DNA sequences is one of the most difficult problems in computational genomics, but it is essential for improving genome annotations and for further comprehensive studies of gene expression and regulation networks. In our work, we integrated specific genome-wide histone modification and DNA sequence features together to predict RNA polymerase II core-promoters in the human genome. Our new predictor outperforms existing promoter prediction algorithms by providing significantly higher sensitivity and specificity at high resolution. We demonstrated that even though the histone modification data used in this study are from a specific cell type, our method can be used to identify both active and repressed promoters. We have applied it to search the upstream regions of microRNA genes, and show that this method can accurately identify the known promoters of the intergenic microRNAs. This result suggests that our new method can help to identify and characterize the core-promoters of both coding and noncoding genes. |
Presented
by:
|
Mr. Wanwan Tang, Tsing Hua University |
| Date: |
14 December 2009 |
| Time: |
16:20-17:05 |
| Venue: |
Seminar Room 1, G/F, Room LG-S1, Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong. |
| Abstract: |
The detection of epistatic interactive effects of multiple genetic variants on the susceptibility of human complex diseases is a great challenge in genome-wide association studies (GWAS). Although methods have been proposed to identify such interactions, the lack of an explicit definition of epistatic effects, together with computational difficulties, makes the development of new methods indispensable. In this talk, we introduce epistatic modules to describe epistatic interactive effects of multiple loci on diseases. On the basis of this notion, we put forward a Bayesian marker partition model to explain observed case-control data, and we develop a Gibbs sampling strategy to facilitate the detection of epistatic modules. Comparisons of the proposed approach with three existing methods on seven simulated disease models demonstrate the superior performance of our approach. When applied to a genome-wide case-control data set for Age-related Macular Degeneration (AMD), the proposed approach successfully identifies two known susceptible loci and suggests that a combination of two other loci is associated with the disease. Further functional analysis supports the speculation that the interaction of these two genetic variants may be responsible for the susceptibility of AMD. |
| |
Presented
by:
|
Dr. CS Yu, Consultant (Psy), KCH |
| |
|
| Chaired
By: |
Dr. Anna Lam, Associate Consultant |
| |
|
| Date: |
3 September 2009 |
| |
|
| Time: |
14:30-15:30 |
| |
|
| Venue: |
J2 Seminar Rm, QMH |
| |
Presented
by:
|
Dr. Andrew Law, Clinical Assistant Professor |
| |
|
| Chaired
By: |
Dr. Phyllis Chan, Consultant |
| |
|
| Date: |
6 August 2009 |
| |
|
| Time: |
14:30-15:30 |
| |
|
| Venue: |
J2 Seminar Rm, QMH |
| |
Presented
by:
|
Dr. CW Law, Associate
Consultant &
Ms. YY Lo, RN |
| |
|
| Chaired
By: |
Dr. CT Lee, MO(Specialist) |
| |
|
| Date: |
2 July 2009 |
| |
|
| Time: |
14:30-15:30 |
| |
|
| Venue: |
J2 Seminar Rm, QMH |
| |
Presented
by:
|
Prof. Nancy Ip, Head &
Chair Professor Department of Biochemistry
Director of Biotechnology Research Institute and Co-Director
of Molecular Neuroscience Center |
| |
|
| Chaired By: |
Dr. CW Law, Associate Consultant |
| |
|
| Date: |
4 June 2009 |
| |
|
| Time: |
14:30-15:30 |
| |
|
| Venue: |
J2 Seminar Rm, QMH |
| |
Presented
by:
|
Prof. KF So, Chair Professor
& Head
Jessie Ho Professor in Neuroscience
Department of Anatomy, HKU |
| |
|
| Chaired By: |
Dr. KH Lau, Associate Consultant |
| |
|
| Date: |
7 May 2009 |
| |
|
| Time: |
14:30-15:30 |
| |
|
| Venue: |
J2 Seminar Rm, QMH |
| |
Speaker:
|
Prof. Brain Leonard who is
a former President of the Collegium Internationale (CINP).
Prof. Leonard published extensively in the field of neuropsychopharmacology.
He is also a highly popular teacher in psychopharmacology
and is the author of the popular textbook "Fundamentals
of Psychopharmacology". In recent years, he focused on
studying the relationship between inflammation, depression
and dementia. |
| |
|
| Date: |
30 April 2009 |
| |
|
| Lunch: |
12:30pm (Buffet lunch sponsored
by Lundbeck Pharmaceuticals) |
| |
|
| Lecture: |
1:15pm-2:00pm |
| |
|
| Venue: |
Seminar room 1,2,3. LKS Faculty
of Medicine, HKU |
| |
|
| Co-organized
by: |
HKU Alzheimer's Disease Research
Network, SRT Healthy Ageing
Department of Psychology, HKU
Department of Psychiatry, LKS Faculty of Medicine, HKU
Dvision of Geriatrics and Neurology, Department of Medicine,
QMH, LKS Faculty of Medicine, HKU
Department of Anatomy, LKS Faculty of Medicine, HKU |
| |
Presented
by: |
Mr. KL Wong,
WM (Psy) |
| |
|
| Chaired By: |
Dr. Carmen Lam, MO |
| |
|
| Date: |
30 April 2009 |
| |
|
| Time: |
14:30-15:30 |
| |
|
| Venue: |
J2 Seminar Rm, QMH |
|