Academic Staff

Prof. Sham

Prof. Pak Chung Sham沈伯松

BA (Cantab), BM BCh (Oxon), MSc (Lond), PhD (Cantab), MRPsych

Director of Academic Developments
Chair Professor in Psychiatric Genomics

Curriculum Vitae (Revised 16th June 2009)
Full Publication list 2010 to 2013
The HKU Scholars Hub Page address:

Research Interests:

  • Genetics and epidemiology of psychiatric disorders

  • Statistical methodology for genetic and epidemiological studies

Publications (Books):

1. Bishop T, Sham PC (2000) Analysis of Multofactorial Disease. Bios, London
2. Sham PC (1998) Statistics in Human Genetics. Arnold Applications of Statistics Series., Edward Arnold, London.

Selected Publication list:

1. The International HapMap Consortium (2005) A haplotype map of the human genome. Nature 437, 1299-1320
2. Lam DH, Hayward P, Watkins ER, Wright K and Sham P (2005) Relapse prevention in patients with bipolar disorder: Cognitive therapy outcome after 2 years. American Journal of Psychiatry 162 (2): 324-329
3. Nash MW, Huezo-Diaz P, Sterne A, Purcell S, Hoda F, Cherny SS, Abecasis GR, Prince M, Gray JA, Ball D, Asherson P, Mann A, Goldberg D, McGuffin P, Farmer A, Plomin R, Craig IW and Sham PC (2004) Genome-wide linkage analysis of a composite index of neuroticism and mood-related scales in extreme selected sibships. Human Molecular Genetics 13 (19): 2173-2182
4. Neale BM, Sham PC (2004) The future of association studies: Gene-based analysis and replication. American Journal of Human Genetics 75 (3): 353-362
5. Sham PC, Rijsdikj FV, Knight J, Makoff A, North B, Curtis D, (2004) Haplotype association analysis of discrete and continuous traits using a mixture of regression models. Behaviour Genetics 34: 207-14
6. Purcell S, Cherny SS, Sham, PC (2003) Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19 (1): 149-50
7. Lam DH, Watkins ER, Hayward P, Bright J, Wright K, Kerr N, Parr-Davis G, Sham P (2003) A randomised controlled study of coginitive therapy for relapse prevention for bipolar affective disorder: outcome of the first year Archives of General Psychiatry 60 (2):145-52
8. McGuffin P, Rijsdijk F, Martin A, Sham P, Katz R, Cardno A (2003) The heritability of bipolar affective disorder and genetic relationship to unipolar depression. Arch Gen Psychiatry 60: 497-502.
9. Chumakov I, Blummenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H, Bougueleret L, Barry C, Tanaka H, La Rosa P, Puech A, Tahri N, Cohen-Akenine A, Delabrosse S, Lissarrague S, Picard FP, Maurice K, Essioux L, Millasseau P, Grel P, Debailleul V, Simon AM, Caterina D, Dufaure I, Malekzadeh K, Belova M, Luan JJ, Bouillot M, Sambucy JL, Primas G, Saumier M, Boubkiri N, Martin-Saumier S,Nasroune M, Peixoto H, Delaye A, Pinchot V, Bastucci M, Guillou S,Chevillon M, Sainz-Fuertes R, Meguenni S, Aurich-Costa J, Cherif D, Gimalac A, Van Duijn C, Gauvreau D, Ouellettte G, Fortier I, Raelson J, sherbatich T, Riazanskaia N, Rogaev E, Raeymaekers P, Aerssens J,Konings F, Luyten W, Macciardi F, Sham PC, Straub RE, Weinberger DR, Cohen D, Ouelettte G, Realson J. (2002) Genetic and physiological data implicating the new human gene G72 and gene for D-amino acid oxidase in schizophrenia. Proc Natl Acad Sci U.S.A. 99 (21): 13675-80.
10. Sham P, Bader JS, Craig I, O'Donovan M, Owen M (2002). DNA pooling: a tool for large-scale association studies. Nature Reviews Genetics, 3:862-871.
11. Sham PC, Purcell S, Cherny SS, Abecasis GR (2002). Powerful regression-based quantitative-trait linkage analysis of general pedigrees. American Journal of Human Genetics, 71:238-253.
12. Sham PC, Purcell S (2001) Equivalence between Haseman-Elston and Variance Components Linkage analysis for sib pairs. American Journal of Human Genetics, 68:1527-1532.
13. Zhao JH, Curtis D, Sham PC ((2000) Model-free analysis and permutation tests for allelic associations. Human Heredity, 50:133-139.
14. Sham PC, Cherny SS, Purcell S, Hewitt JK (2000). Power of linkage versus association analysis of quantitative traits, by use of variance-components models, for sibship data. American Journal of Human Genetics, 66:1616-1630.
15. Sham PC (1998) Statistical methods in psychiatric genetics. Statistical Methods in Medical Research, 7: 279-300
16. Sham PC, Curtis D. (1995) An extended transmission/disequilibrium test (TDT) for multi-allele marker loci. Annals of Human Genetics, 59:323-336.
17. Sham PC, Curtis D. (1995) Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Annals of Human Genetics, 59: 97-105.
18. Sham PC, Jones P, Russell A, Gilvarry K, Bebbington P, Lewis S, Toone B, Murray RM. (1994) Age at onset, sex, and familial psychiatric morbidity in schizophrenia: Report from the Camberwell Collaborative Psychosis Study. British Journal of Psychiatry, 165: 466-473.
19. Sham PC, O'Callaghan E, Takei N, Murray G, Hare E, Murray RM. (1992) Schizophrenia following prenatal exposure to influenza epidemics between 1939 and 1960. British Journal of Psychiatry, 160: 461-466.
20. O'Callaghan E, Sham PC, Takei N, Glover G, Murray RM. (1991) Schizophrenia after the exposure to 1957 A2 influenza epidemic. Lancet, 337: 1248-1250.