Behavioural Genetics and Bioinformatics

Behavioural Genetics and Bioinformatics

We develop statistical and bioinformatic methods for the analysis and integration of genomic and multi-omic data to illucidate the genetic basis and biological mechanisms of neuropsychiatric disorders and related traits. Our special interests include methods for association analysis, power calculations, pathway and network analysis and causal modelling. We have collaborative projects with research groups in Hong Kong, mainland China and overseas institutions, on a range of neuropsychiatric disorders including schizophrenia, bipolar disorder, depression, attention-deficit hyperactivity disorder and epilepsy. Our work has helped to identify novel genetic loci and causal relationships in neuropsychiatric disorders.

Current/Developing projects in Psychiatry:
  • Interactive power calculation for polygenic phenotypes
  • Statistical model for causal relationships between phenotypes
  • Polygenic risk prediction for complex phenotypes
  • Genetics of attention-deficit hyperactivity disorder
  • The role of structural variants in schizophrenia
  • Gene-envrionment interplay in brain abnoralities in depression
Prof. Pak C Sham (Lead)
Dr. Larry Baum
Dr. Zipeng Liu
Dr. Yiming Li
Dr. Yiming Qin
Ms. Talia Wu
Mr. Justin Tubbs