Academic Staff

Dr. Chang





Dr. HUI Lai Ming, Christy 許麗明

BSocSci (Psychology) (HKU), PhD (Psychiatry) (HKU)

Assistant Professor, Department of Psychiatry, HKU
Chairperson of Website committee, Department of Psychiatry, HKU

Vice-Chairperson of Knowledge Development & Transfer of Hong Kong Early Psychosis Foundation (EPISO)
Secretary of Hong Kong Early Psychosis Foundation (EPISO)
Secretary and executive board member of Asian Network of Early Psychosis (ANEP)
Member of Hong Kong Schizophrenia Research Society (SRS)
Member of International Early Psychosis Association (IEPA)

Email: christy@lmhui.com
The HKU Scholars Hub Page address: http://hub.hku.hk/cris/rp/rp01993
Research Gate address: http://www.researchgate.net/profile/Christy_Hui

Biography

Dr Hui is currently an Assistant Professor at the Department of Psychiatry, University of Hong Kong (HKU). She awarded her Doctor of Philosophy (PhD) in 2009 and has been an active researcher in the Psychosis Studies and Intervention programme at the HKU with specific interests in relapse prevention, medication adherence, cognitive dysfunction, early intervention and long-term outcome of early psychosis. The core of her interest is the uncovering of relapse markers in early psychosis using both traditional and innovative neurocognitive paradigms, functional imaging and PET imaging techniques. Understanding of these abnormalities in brain mechanisms and the dopamine dysregulation can provide critical information to understand the disease and its treatment.

Pursuing a research career in the field of psychotic disorders, she published 100 research papers with 40 of them ranked in the top 10th percentile in the field of Psychiatry and Mental Health (including JAMA Psychiatry, Lancet Psychiatry, World Psychiatry, British Journal of Psychiatry, Psychological Medicine and Schizophrenia Research) and top journal in Medicine (including British Medical Journal). She was also awarded the Young Scientist Award twice at the International Schizophrenia Research conference in 2006 and 2008. In 2012, she attained the Doris Zimmern HKU-Cambridge Hughes Hall Fellowship and worked as a research fellow at the University of Cambridge. In 2017, she successfully obtained funding from both the RGC Early Career Scheme (ECS) and the Health and Medical Research Fund (HMRF) in support for her studies on relapse and psychosis.

Research Interests and Focus:

  • Relapse prediction in psychosis
    • Neurocognitive markers and its underlying mechanisms
    • Dopaminergic activity and relapse in patients who discontinued medication
  • Decision on early medication discontinuation or maintenance in remitted first episode psychosis, and its long-term clinical and functional outcome
  • Psychiatrists’ views towards medication discontinuation in remitted first episode psychosis
  • Clinical and cognitive correlates of medication non-compliance 
  • Baseline clinical and cognitive differences and short-term outcome between patients with delusional disorder and schizophrenia
  • Semantic dysfunction, network analysis, and its relationship with change in psychopathology
  • Development and evaluation of Early Intervention Service for psychotic disorders in Hong Kong
  • Women’s mental health

 

Selected Publications:

1.

Hui CLM, William G Honer, Edwin HM Lee, Wing Chung Chang, Sherry KW Chan, Emily SM Chen, Edwin PF Pang, Simon SY Lui, Dicky WS Chung, Wai Song Yeung, Roger MK Ng, William TL Lo, Peter B Jones, Pak Sham, Eric YH Chen (2018). Long-term effects of discontinuation from antipsychotic maintenance following first episode schizophrenia and related disorders. Lancet Psychiatry, DOI: https://doi.org/10.1016/S2215-0366(18)30090-7.

2.

Hui CLM, William G Honer, Edwin HM Lee, Wing Chung Chang, Sherry KW Chan, Emily SM Chen, Edwin PF Pang, Simon SY Lui, Dicky WS Chung, Wai Song Yeung, Roger MK Ng, William TL Lo, Peter B Jones, Pak Sham, Eric YH Chen (2018). Predicting first-episode psychosis patients who will never relapse after 10 years. Psychological Medicine, DOI: https://doi.org/10.1017/S0033291718003070    

3.

Hui CLM, Li YK, Li AWY, Lee EHM, Chang WC, Chan SKW, Lam SY, Thornton AE, Sham P, Honer WG, Chen EYH (2016). Visual working memory deterioration preceding relapse in psychosis. Psychological Medicine, 46(11):2435-2444. 

4.

Hui CLM, Poon VWY, Ko WT, Miao HY, Chang WC, Lee EHM, Chan SKW, Lin J, Chen EYH (2016). Risk factors for antipsychotic medication non-adherence behaviors and attitudes in adult-onset psychosis. Schizophrenia Research, 174:144-149.

5.

Hui CLM, Lee EHM, Chang WC, Chan SKW, Chen EYH (2016). Comparing delusional disorder and schizophrenia – a reply. Psychological Medicine, 46(7):1561-1562.

6.

Hui CLM, Lee EHM, Chang WC, Chan SKW, Lin J, JQ Xu, Chen EYH (2015). Delusional disorder and schizophrenia: a comparison of the neurocognitive and clinical characteristics in first-episode patients. Psychological Medicine, 45(15):3085-3095.

7.

Hui CLM, Poon WY Venessa, Kwok SK Vivian, Chang WC, Chan KW Sherry, Lee HM Edwin, Chen YH Eric (2015). Prevalence and predictors of medication non-adherence among Chinese patients with first-episode psychosis. Psychiatry Research, 228(3):680-687.

8.

Hui CLM, Cindy PY Chiu, YK Li, CW Law, WC Chang, Sherry KW Chan, Edwin HM Lee, Pak Sham, Eric YH Chen (2015). The effect of paternal age on relapse in first-episode schizophrenia. The Canadian Journal of Psychiatry, 60(8):346-353.

9.

Hui CLM, Eric YH Chen (2014). Early medication discontinuation on long-term recovery outcome in first-episode psychosis. JAMA Psychiatry, 71(2):207-208.

10.

Hui CLM, Adrienne WY Li, CM Leung, WC Chang, Sherry KW Chan, Edwin HM Lee, Eric YH Chen (2014). Comparing illness presentation, treatment and functioning between patients with adolescent- and adult-onset psychosis. Psychiatry Research, 220(3):797-802.

11.

Hui CLM, WC Chang, SKW Chan, EHM Lee, WWY Tam, DC Lai, GHY Wong, JYM Tang, FWS Li, KF Leung, Sarah M McGhee, PC Sham, Eric YH Chen (2014). Early intervention and evaluation for adult-onset psychosis: The JCEP study rationale and design. Early Intervention in Psychiatry, 8(3):261-268.

12.

Hui CLM, GHY Wong, JYM Tang, WC Chang, SKW Chan, EHM Lee, MML Lam, CPY Chiu, CW Law, DWS Chung, Steve Tso, EPF Pang, KT Chan, YC Wong, FYM Mo, KPM Chan, SF Hung, William G Honer, Eric YH Chen (2013). Predicting 1-year risk for relapse in patients who have discontinued or continued quetiapine after remission from first-episode psychosis. Schizophrenia Research, 150(1):297-302.

13.

Hui CLM, Carmen Morcillo, Debra A Russo, Jan Stochl, Gillian F Shelley, Michelle Painter, Peter B Jones, Jesus Perez (2013). Psychiatric morbidity, functioning and quality of life in young people at clinical high risk for psychosis. Schizophrenia Research,148,175-180.

14.

Hui CLM, Jennifer YM Tang, CM Leung, Gloria HY Wong, WC Chang, Sherry KW Chan, Edwin HM Lee, Eric YH Chen (2013). A 3-year retrospective cohort study of predictors of relapse in first-episode psychosis in Hong Kong. Australian and New Zealand Journal of Psychiatry, 47(8):746-753.

15.

Hui CLM, Julia Longenecker, GHY Wong, JYM Tang, WC Chang, SKW Chan, EHM Lee, ELW Dunn, MYK Miao, WS Yeung, CK Wong, WF Chan, WN Tang, Eric YH Chen (2012). Longitudinal changes in semantic categorization performance after symptomatic remission from first-episode psychosis: a 3-year follow-up study. Schizophrenia Research, 137(1-3):118-123.

16.

Hui CLM, Yuet-Keung Li, Kwok-Fai Leung, Jennifer Yee-Man Tang, Gloria Hoi-Yan Wong, Wing-Chung Chang, Sherry Kit-Wa Chan, Edwin Ho-Ming Lee, Eric Yu-Hai Chen (2013). Reliability and validity of the Life Functioning Assessment Inventory (L-FAI) for patients with psychosis. Social Psychiatry and Psychiatric Epidemiology, 48:1687-1695.

17.

Hui CLM, Jennifer YM Tang, Gloria HY Wong, WC Chang, Sherry KW Chan, Edwin HM Lee, Eric YH Chen (2013). Predictors of help seeking duration in adult onset psychosis in Hong Kong. Social Psychiatry and Psychiatric Epidemiology, 48(11):1819-1828.

18.

Eric YH Chen, Hui CLM, May ML Lam, Cindy PY Chiu, CW Law, Dicky WS Chung, Steve Tso, Edwin PF Pang, KT Chan, YC Wong, Flora YM Mo, Kathy PM Chan, TJ Yao, SF Hung, William G Honer (2010). Maintenance therapy in patients with remitted first-episode psychosis following one year of treatment: a randomised controlled study comparing discontinuation versus quetiapine. British Medical Journal, 341:c4024

19.

Hui CLM, Eric YH Chen, CS Kan, KC Yip, CW Law, Cindy PY Chiu (2006). Detection of non-adherent behavior in early psychosis. Australian and New Zealand Journal of Psychiatry, 40:446-451.

20.

Eric Yu-Hai Chen, Hui CLM, Eva Lai-Wah Dunn, May Yin-King Miao, Wai-Song Yeung, Chi-Keung Wong, Wah-Fat Chan and Wai-Nang Tang (2005). A prospective 3-year longitudinal study of cognitive predictors of relapse in first-episode schizophrenic patients. Schizophrenia Research, 77(1):99-104.

21. Eric Yu-Hai Chen, Hui CLM, Raymond Chor-Kiu Chan, Eva Lai-Wah Dunn, May Yin-King Miao, Wai-Song Yeung, Chi-Keung Wong, Wah-Fat Chan, and Wai-Nang Tang (2005). A 3-year prospective study of soft neurological signs in first-episode schizophrenia, Schizophrenia Research, 75(1):45-54.
*For a complete list of publications, please visit: http://www.researchgate.net/profile/Christy_Hui

Book Chapters

1.陳友凱, 陳喆燁, 張頴宗, 李浩銘, 許麗明 (2014).《思覺失調個案剖析》中華書局(香港)有限公司.
2.

Christy LM Hui (2013). Medication adherence: specific issues in early psychosis in Asia. In Early psychosis intervention A culturally adaptive clinical guide. (Ed. Eric YH Chen, Helen Lee, Gloria HK Chan and Gloria HY Wong), pp. 273-279. Hong Kong University Press.

3.

Christy LM Hui (2013). Relapse intervention and related issues. In Early psychosis intervention A culturally adaptive clinical guide. (Ed. Eric YH Chen, Helen Lee, Gloria HK Chan and Gloria HY Wong), pp. 283-289. Hong Kong University Press.

Grants

1.

RGC General Research Fund 2017/18: “Effectiveness of mindfulness intervention in prevention of relapse in psychosis” (as PI, HK$971,392)

2.

RGC General Research Fund and Early Career Scheme 2016/17: “Cognitive deterioration and its underlying neurobiological basis in predicting relapse of first-episode psychosis” (as PI, HK$944,034).

3.

Health and Medical Research Fund (HMRF) 2016/17: “Use of in-vivo dopaminergic activity to predict relapse after medication discontinuation in schizophrenia” (as PI, HK$1,178,816).