Academic Staff

Dr. Chan











Dr. CHAN Kit Wa, Sherry 陳喆燁

Clinical Assistant Professor
Chief of Research
Chairperson of Computer and IT Committee
Deputy Director of Master of Psychological Medicine, Psychosis Study
Associate member of the State Key Lab Laboratory of the Brain and Cognitive Science
Department Representative at Committee on CME Programme for Non-specialists
Member of Clinical Interpersonal Skills Course for Medical Students planning Committee

Honorary Associate Consultant, Queen Mary Hospital & Kwai Chung Hospital
Council member of the Hong Kong College of Psychiatrists
Vice-Chairperson of Knowledge Development and Transfer, EPISO Hong Kong (an NGO with main aim to promote public awareness of psychosis)
Member of Work Group for development of Early Intervention Service in Hong Kong - The Hospital Authority (Chairperson for Training and Public awareness subcommittees)
Email: kwsherry@hku.hk
The HKU Scholars Hub Page address:http://hub.hku.hk/rp/rp00539

Award:

  • Distinguished Young Fellow of Hong Kong Academy of Medicine 2016
  • World Psychiatric Association Regional Congress 2014 (Best Poster Award)
  • Health Research Symposium Hong Kong 2014 (Best Poster Award)

Short Biography:

My main research interests are in the evaluation of early intervention service, Longitudinal outcomes of psychosis, Treatment resistant schizophrenia, Psychopathology (particularly insight and delusion) and its neurobiological basis, Metacognition and insight, psychotic-like experience

Research Interests:

  1. Clinical Insight in schizophrenia
  2. Though there have been many studies exploring clinical and cognitive correlates of insight in patients with schizophrenia, mostly were with cross-sectional approach and with patients of different stage of illness. One of our studies examined clinical and cognitive correlates in drug naive patients with schizophrenia and the other study looked at longitudinal changes of relationship of insight and cognition. Another study explored the relationship between medication adherence, insight and knowledge about the illness.
    a. Chan KW, Hui LM, Wong HY, Lee HM, Chang WC, Chen YH. Medication adherence, knowledge about psychosis, and insight among patients with a schizophrenia-spectrum disorder. J Nerv Ment Dis. 2014 Jan;202(1):25-9. PubMed PMID: 24375208.
    b. Chan SK, Chan KK, Hui CL, Wong GH, Chang WC, Lee EH, Tang JY, Chen EY. Correlates of insight with symptomatology and executive function in patients with first-episode schizophrenia- spectrum disorder: a longitudinal perspective. Psychiatry Res. 2014 May 15;216(2):177-84. PubMed PMID: 24560612.
    c. Chan SK, Chan KK, Lam MM, Chiu CP, Hui CL, Wong GH, Chang WC, Chen EY. Clinical and cognitive correlates of insight in first-episode schizophrenia. Schizophr Res. 2012 Mar;135(1-3):40-5. PubMed PMID: 22245186.
  3. Evaluation of Long term outcomes of early intervention of psychosis service
  4. One of the key questions in establishing the early intervention service for psychosis is whether the shortterm effect of the early intervention service can sustain in the long term. The early intervention service in different countries is usually about 2-3 years. There has been some studies on the medium term effect of early intervention service such as 5-7 years, studies on longer term effect is limited. We have conducted studies systematically evaluating 10-year outcomes of early intervention service comparing with the standard care and results have contributed to this gap of research.
    a. Chan SK, Chau EH, Hui CL, Chang WC, Lee EH, Chen EY. Long term effect of early intervention service on duration of untreated psychosis in youth and adult population in Hong Kong. Early Interv Psychiatry. 2016 Jan 23;PubMed PMID: 26801970.
    b. Chan SK, Chen EY, Tang JY, Chiu CP, Lam MM, Chung DW, Tso S, Hung SF, Yip KC, DunEL. Early intervention versus standard care for psychosis in Hong Kong: a 10-year study. Hong Kong Med J. 2015 Apr;21 Suppl 2:19-22. PubMed PMID: 25852097.
    c. Chan SK, So HC, Hui CL, Chang WC, Lee EH, Chung DW, Tso S, Hung SF, Yip KC, Dunn E, Chen EY. 10-year outcome study of an early intervention program for psychosis compared with standard care service. Psychol Med. 2015 Apr;45(6):1181-93. PubMed PMID: 25233868.
  5. Public stigma of psychosis
  6. Public stigma on psychosis is one of the major barriers towards help seeking and patient recovery. It is also likely to be related to the development of self-stigma and insight deficit. We have explored factors contributing to the public stigma in order to support further development of effective intervention. Our finding further suggested gender specific intervention should be considered.
    a. Chan SK, Lee KW, Hui CL, Chang WC, Lee EH, Chen EY. Gender effect on public stigma changes towards psychosis in the Hong Kong Chinese population: a comparison between population surveys of 2009 and 2014. Soc Psychiatry Psychiatr Epidemiol. 2016 Dec 1;PubMed PMID: 27909775.
    b. Chan SK, Tam WW, Lee KW, Hui CL, Chang WC, Lee EH, Chen EY. A population study of public stigma about psychosis and its contributing factors among Chinese population in Hong Kong. Int J Soc Psychiatry. 2016 May;62(3):205-13. PubMed PMID: 26721540.
    c. Chan SK, Ching EY, Lam KS, So HC, Hui CL, Lee EH, Chang WC, Chen EY. Newspaper coverage of mental illness in Hong Kong between 2002 and 2012: impact of introduction of a new Chinese name of psychosis. Early Interv Psychiatry. 2015 Nov 23;PubMed PMID: 26593744.
  7. Reference delusion in psychosis
  8. Reference delusion is one of the commonest delusion in patients with psychosis. Typically, patients believe that non-self-related events are relevant to self eg believe others are looking at self but others are not, named as self-referential gaze perception. Self-referential gaze perception is also highly relevant in social cognition. I have developed a behavioral paradigm in looking into this phenomenon in different populations, first episode patients, patients in remission and those in prodromal state to explore it underlying mechanisms.
      General Research Fund (GRF) - Exploring the mechanisms of self-referential gaze perception and its potential as an endophenotype in patients with schizophrenia-spectrum disorder, 800,791 (1/1/2016-31/12/2018)
  9. Treatment resistant schizophrenia
  10. Thought antipsychotic medication is effective in ameliorate positive symptoms of patients with schizophrenia, about 20-40% of patients are not responding to the current form of antipsychotic medications and are considered as treatment resistant state. They are often the group of patients with poorer outcomes and require more health care resources. Clozapine is the only antipsychotic medication is found to be effective in treating treatment resistant schizophrenia, yet only about 60% patients are responding. Therefore understanding the mechanisms of treatment resistant schizophrenia and predictors can help to improve our care to this group of patients.
      Health and Medical Research Fund - Full Grant: Treatment resistance following the first-episode schizophrenia-spectrum disorder: a retrospective case-control study. Funded by the Health Bureau of Hong Kong, HK$799,952 (Two year funding from 2014, completed)

Complete List of Published Work in My Bibliography:

http://bit.ly/2lXWKb3

Research Grants

Eexternal research grants funded as Principal Investigator
  a. Health and Health Service Research Grant: A 10-year outcome study of an early Intervention program for psychosis in Hong Kong (EASY) compare with standard care service. Funded by the Health Bureau of Hong Kong, HK$784.702 (Two year funding from 2010, completed)
  b. Health and Medical Research Fund - Full Grant: Treatment resistance following the first-episode schizophrenia-spectrum disorder: a retrospective case-control study. Funded by the Health Bureau of Hong Kong, HK$799,952 (Two year funding from 2014, completed)
  c. Health and Medical Research Fund - Full Grant: Psychotic-like experiences (PLEs) in the general population of Hong Kong: a two-year prospective follow up study. Funded by the Health Bureau of Hong Kong, HK$877,352 (Two year funding from 2014, completed)
  d.

General Research Fund (GRF) - Exploring the mechanisms of self-referential gaze perception and its potential as an endophenotype in patients with schizophrenia-spectrum disorder, 800,791  (1/1/2016-31/12/2018)