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A Transdiagnostic Computational Architecture of Social Decision-Making

Departmental Research Seminar

Presented by: 

Mr Tsui Kam Hung Harry (PhD candidate, Department of Psychiatry, SClinMed, HKU)

Chaired by:

Professor CHAN Kit Wa, Sherry (Clinical Associate Professor, Department of Psychiatry, SClinMed, HKU)

Date:

12 March 2026

Time:

8:00 am

-

8:45 am

Venue:

Lecture Room 211 A&B, 2/F, New Clinical Building, Queen Mary Hospital

Abstract:

Understanding others’ mental states is essential for social interaction, yet it fundamentally involves inference under uncertainty. The brain must transform noisy perceptual input into socially meaningful interpretations. I will present a computational framework that models this process as evidence accumulation under uncertainty. We applied hierarchical drift diffusion modeling to decompose social judgments into mechanistic components across participants spanning schizophrenia-spectrum disorder, bipolar disorder, depression. We found that impairments were specific to evidence accumulation under ambiguity and were shared across diagnoses. Archetypal analysis revealed distinct social decision-making strategies expressed dimensionally across individuals. A profile characterized by efficient evidence accumulation was associated with lower symptoms and better functioning. This work illustrates how computational modeling can bridge social cognition, psychiatric heterogeneity, and functional outcomes within a unified framework.

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