Transcranial pulse stimulation (TPS), as a new non-invasive brain stimulation approach, has been shown to effectively improve cognition in people with Alzheimer's Disease. But the feasibility of applying TPS in people with mild Neurocognitive Disorders (NCD) remained unknown. The effectiveness and tolerability of TPS with neuro-navigation in old-age adults with mild NCD has been examined with clinical and biochemical assessments, and by structural and resting state functional neuroimaging before and after the intervention. Significant cognitive improvements were observed in mild NCD subjects with no serious adverse effect reported after TPS intervention. The fMRI results analysis provided further explanation for the treatment effect.