Genome-wide association analysis of age-at-onset in schizophrenia
Departmental Research Seminar
Ms. ZHAN Na (PhD candidate)
Dr. LEE Ho Ming, Edwin (Clinical Assistant Professor)
24 March 2022
Schizophrenia is typically diagnosed in late adolescence and early twenties; however, around 5% of cases happen before 18 and are usually defined as early-onset schizophrenia. The early-onset patients tend to present with increased severity and poor prognosis compared to the onset in adulthood. As a complex disorder, schizophrenia was estimated to have a heritability of 60%-80%, and this analysis aims to test if there is an association between genetic variants and age-at-onset in this disorder.
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