Genome-wide association analysis of age-at-onset in schizophrenia

Schizophrenia is typically diagnosed in late adolescence and early twenties; however, around 5% of cases happen before 18 and are usually defined as early-onset schizophrenia. The early-onset patients tend to present with increased severity and poor prognosis compared to the onset in adulthood. As a complex disorder, schizophrenia was estimated to have a heritability of 60%-80%, and this analysis aims to test if there is an association between genetic variants and age-at-onset in this disorder.

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Session 2: https://hku.zoom.us/meeting/register/tJ0ofu-hpjIoHtcZWPpAgzyRt3M4AnUsBlcP