top of page
wcchang_edited.jpg

Dr. CHANG Wing Chung 張頴宗

MBChB (CUHK), MD (HK), FRCPsych(UK), FHKCPsych, FHKAM(Psychiatry)

Clinical Associate Professor

Assistant Dean (Well-being) of LKS Faculty of Medicine

Department Chairperson
Principal Investigator of the State Key Laboratory of Brain & Cognitive Sciences
Honorary Consultant, Queen Mary Hospital
MBBS Curriculum Committee (MBCC) Member

Member of Departmental Research Postgraduate Committee

Convener of HA EASY Programme Evaluation Workgroup
Chairman of Research Committee, HK College of Psychiatrists
Secretary of Hong Kong Schizophrenia Research Society
Executive Board Member of Asian Network of Early Psychosis (ANEP)
Editorial Board Member of East Asian Archives of Psychiatry

Email: changwc@hku.hk
The HKU Scholars Hub Page address: http://hub.hku.hk/rp/rp01465
ORCID: 0000-0002-3581-8895

To apply for research postgraduate study (MPhil & PhD), please email Dr. WC Chang with your research proposal and CV for further information

Biography

Dr. WC Chang has joined the Department of Psychiatry, HKU since 2011. He is currently a Clinical Associate Professor, a Principal Investigator of the State Key Laboratory of Brain & Cognitive Sciences, and an Honorary Consultant at the Department of Psychiatry, Queen Mary Hospital. He is a Fellow of the Royal College of Psychiatrists (UK) and HK College of Psychiatrists. He has received several research awards over the past few years including Clinical Research Fellowship by HK Research Grants Council and Distinguished Young Fellow by the HK Academy of Medicine and in 2014, IEPA (International Early Psychosis Association) Young Investigator Award and NARSAD Young Investigator Award by Brain & Behavior Research Foundation of United States in 2016. He has been ranked as HKU Scholar in the Top 1% (by Clarivate Analytics in the top 1% worldwide by citations in psychiatry) since 2019. His research focuses on early intervention for psychosis, negative symptoms and motivational impairment, longitudinal outcome of first-episode psychosis, at-risk mental state (clinical high-risk) and psychosis prediction, impact of severe mental illness on physical health, and outcomes of early-stage bipolar disorder.

Research Interests:

1. Evaluation of early interventions for first-episode psychosis

Early intervention (EI) for psychosis has been the major focus of mental health service development worldwide in the past decade. Hong Kong is among the first few regions in Asia implementing EI service (namely EASY or Early Assessment Service for Young people with psychosis) for first-episode psychosis (FEP) patients. Although evidence indicates superior efficacy of EI over generic psychiatric care on outcome improvement in FEP, sustainability of positive effects and optimal duration for EI remain to be clarified. Our research team was the first to conduct RCT addressing effectiveness of EI service with its treatment duration beyond usual 2-year period, and demonstrated that extended 3-year EI was superior to 2-year EI in symptom and functional improvement in FEP patients (Chang et al. 2015). Our recently completed 2-year post-RCT follow-up study, however, revealed that initial therapeutic benefits of extended EI could not be sustained after termination of EI (Chang et al. 2017), indicating that further research is warranted to identify patient subgroups who may benefit most from extended intensive EI and active therapeutic elements for sustained effects. Our team has also recently completed a territory-wide evaluation study on the effectiveness of a newly-implemented EASY expansion (EASY+) to cover FEP patients aged 15-64 years with 3-year EI service. Our preliminary results showed that patients received EASY+ care had shorter treatment delay, fewer depressive and negative symptoms, and better functioning and quality of life than those managed in standard service.

Selected Related publications

  1. Ho RWH, Chang WC*, Kwong VWY, et al. Prediction of self-stigma in early psychosis: 3-year follow-up of the randomized-controlled trial on extended early intervention. Schizophrenia Research 2018;195:463-468.

  2. Chang WC, Kwong VWY, Lau ESK, et al. Sustainability of treatment effect of 3-year early intervention programme for first-episode psychosis. British Journal of Psychiatry 2017;211:37-44.

  3. Chang WC, Kwong VWY, Chan GHK, et al. Prediction of functional remission in first-episode psychosis: 12-month follow-up of the randomized-controlled trial on extended early intervention in Hong Kong. Schizophrenia Research 2016;173:79-83.

  4. Chang WC, Chan GHK, Jim OTT, et al. Optimal duration of an early intervention programme for first-episode psychosis: randomised controlled trial. British Journal of Psychiatry 2015; 206 :492-500

  5. Chan TCW, Chang WC*, Hui CLM, et al. Rate and predictors of disengagement from a 2-year early intervention program for psychosis in Hong Kong. Schizophrenia Research 2014;153:204-208.

​

Manuscript reporting major findings of EASY+ evaluation study is currently under preparation.

2. Negative symptoms: early course, impacts and neurocognitive mechanisms

Negative symptoms are a core feature of schizophrenia and related psychoses, and represent an unmet therapeutic need, associated with functional disability and limited treatment response. We have systematically investigated negative symptoms in first-episode schizophrenia (FES) encompassing the early course of symptom development, impacts on illness outcomes, and neurocognitive mechanisms underlying symptom manifestation (esp. motivational impairment). Our results show that around one-fourth of FES patients developed persistent negative symptoms over 3 years after treatment initiation. Negative symptom severity was predicted by prolonged duration of untreated psychosis and poor premorbid adjustment. Furthermore, amotivation domain of negative symptom construct was found to be the most robust predictor of functional outcome, above and beyond the contributions of cognitive dysfunction, diminished expression (another negative symptom subdomain) and other symptom dimensions in FES. Importantly, EI service was shown to be effective in ameliorating negative symptoms, particularly motivational impairment. Alongside, we have recently initiated a series of studies, applying several promising translational research paradigms in FEP patients, with an aim to clarify neurocognitive mechanisms underlying manifestation of motivational impairment, including reinforcement learning, risky decision-making and effort-based decision making (physical effort-cost allocation and cognitive effort discounting).

Selected Related publications

  1. Chang WC*, Ho RWH, Tang JYM, Wong CSM, Hui CLM, Chan SKW, Lee EMH, Suen YN, Chen EYH. Early-stage negative symptom trajectories and relationships with 13-year outcomes in first-episode non-affective psychosis. Schizophrenia Bulletin 2019;45:610-619.

  2. Chang WC, Liu JTT, Hui CLM, et al. Executive dysfunctions differentially predict amotivation in first-episode schizophrenia-spectrum disorder: a prospective 1-year follow-up study. European Archives of Psychiatry and Clinical Neuroscience 2018 Jun 22. doi: 10.1007/s00406-018-0918-y. [Epub ahead of print]

  3. Chang WC, Kwong VWY, Or PCF, Lau ESK, Chan GHK, Jim OTT, Hui CLM, Chan SKW, Lee EMH, Chen EYH. Motivational impairment predicts functional remission in first-episode psychosis: 3-year follow-up of the randomized-controlled trial on extended early intervention. Australian and New Zealand Journal of Psychiatry 2018;52:1194-1201.

  4. Chang WC, Kwong VWY, Hui CLM, et al. Relationship of amotivation to neurocognition, self-efficacy and functioning in first-episode psychosis: a structural equation modeling approach. Psychological Medicine 2017;47:755-765.

  5. Chang WC, Kwong VWY, Chan GHK, et al. Prediction of motivational impairment: 12-month follow-up of the randomized-controlled trial on extended early intervention for first-episode psychosis. European Psychiatry 2017;41:37-41.

  6. Chang WC, Lau CFC, Chan SSI, et al. Premorbid, clinical and cognitive correlates of primary negative symptoms in first-episode psychosis. Psychiatry Research 2016;242:144–149.

  7. Chang WC, Hui CLM, Chan SKW, Lee EHM, Chen EYN. Impact of avolition and cognitive impairment on functional outcome in first-episode schizophrenia-spectrum disorder: a prospective one-year follow-up study. Schizophrenia Research 2016;170:318-321.

  8. Chang WC, Lau CFC, Chan SSI, et al. Premorbid, clinical and cognitive correlates of primary negative symptoms in first-episode psychosis. Psychiatry Research 2016;242:144–149.

  9. Chang WC, Hui CLM, Chan SKW, et al. Relationship between diminished expression and cognitive impairment in first-episode schizophrenia: a prospective three-year follow-up study. Schizophrenia Research 2014; 152:146-151.

  10. Chang WC, Hui CLM, Tang JYM, et al. Impacts of duration of untreated psychosis on cognition and negative symptoms in first-episode schizophrenia: a 3-year prospective follow-up study. Psychological Medicine 2013, 43: 1883-1894.

  11. Chang WC, Tang JYM, Hui CLM, et al. The relationship of early premorbid adjustment with negative symptoms and cognitive functions in first-episode schizophrenia: a prospective three-year follow-up study. Psychiatry Research 2013, 209: 353-360.

  12. Chang WC, Hui CLM, Tang JYM, et al. Persistent negative symptoms in first-episode schizophrenia: a prospective three-year follow-up study. Schizophrenia Research 2011; 133:22-28

3. Longitudinal outcomes of first-episode psychosis

Schizophrenia and related psychoses are severe mental illnesses constituting one of the leading causes of disability worldwide. To further our understanding on longitudinal course of illness and longer-term outcome predictors, we have conducted a number of prospective follow-up studies on FEP cohorts. Our research included investigations of impacts of duration of untreated psychosis, premorbid adjustment, generalized and specific cognitive impairment, and various symptom dimensions on clinical and functional outcomes. In particular, we have examined prevalence and risk factors predicting suicidal ideation, suicidal behavior and physical violence in the early stage of psychotic disorder. We have also evaluated factors predicting subsequent attainment of symptomatic remission, functional remission, recovery and sustained employment, which are the key milestones along the course of treatment for FEP. We have recently adopted individual-based trajectory analysis (growth mixture modeling) to examine the longitudinal patterns of functioning over the first 3 years of treatment for FEP so as to better characterize course of illness and hence to facilitate development of targeted intervention to promote early and sustained recovery.

Selected Related publications

  1. Chang WC*, Ho RWH, Tang JYM, Wong CSM, Hui CLM, Chan SKW, Lee EMH, Suen YN, Chen EYH. Early-stage negative symptom trajectories and relationships with 13-year outcomes in first-episode non-affective psychosis. Schizophrenia Bulletin 2019;45:610-619.

  2. Chang WC*, Chu AOK, Kwong VWY, et al.  Patterns and predictors of trajectories for social and occupational functioning in patients presenting with first-episode non-affective psychosis: a three-year follow-up study. Schizophrenia Research 2018 doi: 10.1016/j.schres.2018.01.021

  3. Kwong VWY, Chang WC*, Chan GHK, et al. Clinical and treatment-related determinants of subjective quality of life in patients with first-episode psychosis. Psychiatry Research 2017;249:39-45.

  4. Chang WC, Lau ESK, Chiu SSY, et al. Three-year clinical and functional outcome comparison between first-episode mania with psychotic features and first-episode schizophrenia. Journal of Affective Disorders 2016;200:1-6.

  5. Chang WC, Chan SSI, Hui CLM, et al. Prevalence and risk factors for violent behavior in young people presenting with first-episode psychosis in Hong Kong: a three-year follow-up study. Australian and New Zealand Journal of Psychiatry 2015; 49:914-922.

  6. Chang WC, Cheung R, Hui CLM, et al. Rate and risk factors of depressive symptoms in Chinese patients presenting with first-episode non-affective psychosis in Hong Kong. Schizophrenia Research 2015;168:99–105.

  7. Chang WC, Chen ESM, Hui CLM, et al. Prevalence and risk factors for suicidal behavior in young people presenting with first-episode psychosis in Hong Kong: a three-year follow-up study. Social Psychiatry and Psychiatric Epidemiology 2015;50:219-226.

  8. Chang WC, Chen ESM, Hui CLM, et al. The relationships of suicidal ideation with symptoms, neurocognitive function, and psychological factors in patients with first-episode psychosis. Schizophrenia Research 2014;157:12-18.

  9. Chang WC, Tang JWM, Hui CLM, et al. Clinical and cognitive predictors of vocational outcome in first-episode schizophrenia: a prospective three-year follow-up study. Psychiatry Research 2014, 220:834-839.

  10. Chang WC, Hui CLM, Wong GHY et al., Symptomatic remission and cognitive impairment in first-episode schizophrenia: a prospective 3-year follow-up study. Journal of Clinical Psychiatry 2013; 74:e1046-e1053.

  11. Chang WC, Tang JYM, Hui CLM, et al. Duration of untreated psychosis: relationship with baseline characteristics and three-year outcome in first-episode psychosis. Psychiatry Research 2012; 198:360-365.

  12. Chang WC, Chan TCW, Chen ESM, et al. Concurrent and predictive validity of symptomatic remission criteria in first-episode schizophrenia. Schizophrenia Research 2013, 143:107-115.

  13. Chang WC, Tang JY, Hui CL, et al. Prediction of remission and recovery in young people presenting with first-episode psychosis in Hong Kong: a 3-year follow-up study. Australian and New Zealand Journal of Psychiatry 2012; 46:100-108.

4. Reinforcement learning, risk-taking & effort-based decision-making in early psychosis

Reinforcement learning (RL) has been regarded as a promising paradigm for translational research in schizophrenia and related psychoses. Reward processing is closely associated with dopamine, which is a key neurotransmitter dysregulated in psychosis, and the primary target of current drug treatment. Brain systems involved in reward processing are implicated in psychosis development. Reward system also provides a useful theoretical framework linking symptom manifestations to neurobiological dysfunction underlying psychosis. Literature indicated that chronic schizophrenia patients had RL impairment. Nonetheless, such impairment in the early stage of psychotic illness, within which confounding effects of antipsychotic exposure and illness duration on RL could be minimized, has been under-studied. Further, RL may be a useful candidate in psychosis prediction from at-risk mental state (ARMS). Our research team conducts prospective follow-up study in both FES and ARMS samples to examine the presence and degree of RL deficit, and its relationship with symptom and cognitive functions. A group of antipsychotic-naive FES patients are also examined before and 6-week after antipsychotic treatment commencement to clarify the potential confounding effect of antipsychotic medications on RL and the potential clinical utility of RL in predicting treatment response. We also examined RL performance in unaffected siblings of FES patients to clarify whether RL can be useful endophenotype for schizophrenia research. Both behavioral and functional MRI data are collected for detailed and systematic investigation. Our findings of RL performance on clinically-stabilized FES sample have recently been published, suggesting the presence of mild RL deficits but preserved value-guided decision-making ability in the initial stage of illness.

Related publications

  1. Chang WC*, Westbrook A, Strauss G, Chu AOK, Chong CSY, Siu CMW, Chan SKW, Lee EHM, Hui CLM, Suen YM, Lo TL, Chen EYH. Abnormal cognitive effort allocation and its association with amotivation in first-episode psychosis. Psychological Medicine 2019 doi: 10.1017/S0033291719002769. [Epub ahead of print]

  2. Chang WC*, Chu AOK, Treadway MT, Strauss GP, Chan SKW, Lee EHM, Hui CLM, Suen YN, Chen EYH. Effort-based decision-making impairment in patients with clinically-stabilized first-episode psychosis and its relationship with amotivation and psychosocial functioning. European Neuropsychopharmacology 2019;29(5):629-642.

  3. Luk MSK, Chang WC*, Chong CSY, Siu CMW, Chan SKW, Lee EMH, Hui CLM, Sun YN, Lee TMC, Lo TL, Chen EYH. Altered risky decision-making in patients with early non-affective psychosis. European Archives of Psychiatry and Clinical Neuroscience 2019 doi: 10.1007/s00406-019-00994-2. [Epub ahead of print]

  4. Chang WC, Waltz JA, Gold JM, Chan TCW, Chen EYH. Mild reinforcement learning deficits in patients with first-episode psychosis. Schizophrenia Bulletin 2016;42:1476-1485.

​

Three papers are under preparation:

  1. Chang WC, Lee HC, Wo SF, et al. Reinforcement learning impairment and its relationship with primary negative symptoms in individuals at clinical high-risk for psychosis

  2. Chang WC, Lee HC, Wo SF, et al. Reinforcement learning deficits in antipsychotic-naïve first-episode psychosis patients

  3. Chang WC, Lee HC, Wo SF, et al. Reinforcement learning impairment in first-episode schizophrenia patients and their unaffected siblings

5. At-risk mental state (ARMS) research on psychosis prediction

Individuals ascertained as at-risk mental state (ARMS or clinical high-risk) by standardized operational clinical criteria have a markedly elevated rate of developing psychotic disorder (20-30%) over 2 to 3 years. ARMS individuals also exhibit pronounced functional impairment and are associated with high rate of comorbid mood disorders and heighted suicide risk. In order to better characterize clinical course of ARMS individuals, we have conducted a naturalistic 2-year prospective follow-up of 110 ARMS subjects (ARMS100 study). Recently, we have incorporated multi-modal neuroimaging measurement including structural MRI, DTI, resting-state fMRI and proton MRS, alongside clinical, cognitive and functional assessments, into our ongoing ARMS cohort study with an aim to develop a robust biomarker-based prediction model for psychosis transition and illness outcome. In addition, potential role of reinforcement learning in predicting conversion to psychosis from ARMS is under investigation.

Related publications

  1. Chang WC*, Ng CN, Chan KN, Lee HC, Chan SI, Chiu SY, et al. Psychiatric comorbidity in individuals at-risk for psychosis: relationships with symptoms, cognition and psychosocial functioning. Early Intervention in Psychiatry 2020 (in press)

  2. Chu AOK, Chang WC*, Chan SKW, Lee EMH, Hui CLM, Chen EYH. Comparison of cognitive functions between first-episode schizophrenia patients, their unaffected siblings and individuals at clinical high-risk for psychosis. Psychological Medicine 2019;49:1929-1936.

  3. Chang WC, Lee HC, Chan SI, et al. Negative symptom dimensions differentially impact on functioning in individuals at-risk for psychosis. Schizophrenia Research 2018 Jun 20. pii: S0920-9964(18)30375-X. doi: 10.1016/j.schres.2018.06.041. [Epub ahead of print]

 

One paper is under review:

  1. Chan KN, Chang WC*, Ng CM, Lee HC, Chan SI, Chiu SY, et al. Gender differences in symptom severity, cognition and psychosocial functioning among individuals with at-risk mental state for psychosis.

6. Epidemiological investigation of prevalence & correlates of psychotic disorders in Hong Kong

Epidemiological investigation of psychotic disorders is of great importance. Hong Kong Mental Morbidity Survey (HKMMS) is the first territory-wide, population-based epidemiological study in Hong Kong which examines prevalence of several major mental disorders including psychotic disorders. This study evaluated 5700 randomly-selected households from the community. Our recently published findings demonstrate that around 2.5% of HK general population suffers from life-time psychotic disorder. This indicates a huge societal burden imposed by severe mental illness, and underscores a major challenge to on both public health and psychiatric services in HK. Our further analyses of HKMMS psychosis study will focus on psychosocial correlates associated with psychotic disorder with clinically significant comorbid mood symptoms, and potential impacts of psychosis on general well-being and physical health.

Related publications

  1. Chang WC, Wong CSM, Chen EYH, et al. Lifetime prevalence and correlates of schizophrenia-spectrum, affective, and other non-affective psychotic disorders in the Chinese adult population. Schizophrenia Bulletin 2017; 43:1280-1290.

​

One paper is under preparation

  1. Wong CSM, Chang WC*, Ng MCM, et al. Prevalence and correlates of physical morbidities in individuals with psychotic disorders in Hong Kong: a population-based epidemiological survey

7. Impact of severe mental disorders and psychotropics on physical health

Mental disorders, in particular severe mental disorders (schizophrenia-spectrum disorders and bipolar disorders), are associated with markedly elevated risk of premature mortality, physical morbidity, and substantially shortened life expectancy relative to the general population. Critically, such differential mortality gap persists or has even widened in recent decades, indicating that physical health disparities experienced by people with mental disorders represent a serious global health problem and rectifying the lifespan inequalities is considered an international health priority. We have recently conducted a series of population-based studies examining excess mortality, physical comorbidity and reduced lifespan in schizophrenia and bipolar disorder, increased mortality risk following stroke and acute coronary syndrome in psychotic disorder patients, meta-analyses evaluating the findings on receipt of invasive cardiac procedure and cardioprotective medications after acute coronary syndrome in schizophrenia patients, and life expectancy across a wide spectrum of mental disorders, to name a few. 

Related publications

  1. Chang WC*, Chan JKN, Wong CSM, Hai JSH, Or PCF, Chen EYH. Mortality, revascularization and cardioprotective pharmacotherapy after acute coronary syndrome in patients with psychotic disorders: a population-based cohort study. Schizophrenia Bulletin 2020;46:774-784.

  2. Yung NCL, Wong CSM, Chan JKN, Chen EYH, Chang WC*. Excess mortality and life-years lost in people with schizophrenia and other non-affective psychoses: an 11-year population-based cohort study. Schizophrenia Bulletin 2021;47:474-484.

  3. Chan JKN, Wong CSM, Or PCF, Chen EYH, Chang WC*. Risk of mortality and complications in patients with schizophrenia and diabetes mellitus: a population-based cohort study. British Journal of Psychiatry 2021;219:375-382.

  4. Chan JKN, Wong CSM, Yung NCL, Chen EYH, Chang WC*. Excess mortality and life-years lost in people with bipolar disorder: an 11-year population-based cohort study. Epidemiology and Psychiatric Sciences 2021;30:e39.

  5. Chan JKN, Tong CHY, Wong CSM, Chen EYH, Chang WC*. Life expectancy and years of potential life lost in bipolar disorder: a systematic review and meta-analysis. British Journal of Psychiatry 2022;221(3):567-576.

  6. Chan KN, Chu ST, Hung C, Law WY, Wong CM, Chang WC*. Mortality, revascularization and cardioprotective pharmacotherapy after acute coronary syndrome in patients with severe mental illness: a systematic review and meta-analysis. Schizophrenia Bulletin 2022;48(5):981-998.

  7. Chan JKN, Correll CU, Wong CSM, Chu RST, Fung VSC, Wong GHS, Lei JHC, Chang WC*. Life expectancy and years of potential life lost in people with mental disorders: a systematic review and meta-analysis. eClinical Medicine 2023;65:102294.

Current Research Projects (as PI):

  1. ARMS100 study: prospective follow-up of at-risk mental state (ARMS) for psychosis and outcome prediction

  2. A multimodal MRI and proton MRS investigation of at-risk mental state (ARMS) for psychosis

  3. Reinforcement learning in first-episode psychosis, clinical & genetic high-risk for psychosis

  4. Evaluation of extended EASY programme for adult first-episode psychosis patients (EASY+ Study)

  5. Experimental investigation of aberrant neurocognitive mechanisms for delusions in first-episode psychosis (3D-Study)

  6. Multimodal investigation of motivational impairment in first-episode psychosis: experience-sampling method (ESM) and effort-allocation paradigm approaches

  7. Early-stage bipolar disorder: risky decision-making, reinforcement learning, and cognitive & affective ToM investigations

  8. Comparison of first-episode schizophrenia & first-episode bipolar disorder on neurocognitive and neuroimaging measures

  9. Impacts of severe mental illness on physical health

  10. Probing brain abnormalities in epidemiologically-derived youth cohort with subclinical psychosis symptoms (HKYES)

Selected Publications (first author/corresponding author*):

  1. Chang WC, Strauss GP, Ahmed AO, Wong SCY, Chan JKN, Lee EHM, Chan SKW, Hui CLM, James SH, Chapman HC, Chen EYH. The latent structure of negative symptoms in individuals with attenuated psychosis syndrome and early psychosis: support for the 5 consensus domains. Schizophrenia Bulletin 2021; 47:386-394.

  2. Chang WC*, Chan JKN, Wong CSM, Hai JSH, Or PCF, Chen EYH. Mortality, revascularization and cardioprotective pharmacotherapy after acute coronary syndrome in patients with psychotic disorders: a population-based cohort study. Schizophrenia Bulletin 2020; 46:774-784.

  3. Chang WC*, Wong CSM, Or PCF, Chu AOK, Hui CLM, Chan SKW, Lee EHM, Suen YN, Chen EYH. Inter-relationships among psychopathology, premorbid adjustment, cognition, and psychosocial functioning in first-episode psychosis: a network analysis approach. Psychological Medicine 2020; 50:2019-2027.

  4. Chang WC*, Ho RWH, Tang JYM, Wong CSM, Hui CLM, Chan SKW, Lee EMH, Suen YN, Chen EYH. Early-stage negative symptom trajectories and relationships with 13-year outcomes in first-episode non-affective psychosis. Schizophrenia Bulletin 2019; 45:610-619.

  5. Chang WC*, Wong CSM, Chen EYH, Lam LCW, Chan WC, Ng RMK, Hung SF, Cheung EFC, Sham PC, Chiu HFK, Lam M, Lee EHM, Chiang TP, Chan LK, Lau GKW, Lee ATC, Leung GTY, Leung JSY, Lau JTF, van Os J, Lewis G, Bebbington P. Lifetime prevalence and correlates of schizophrenia-spectrum, affective, and other non-affective psychotic disorders in the Chinese adult population. Schizophrenia Bulletin 2017; 43:1280-1290.

  6. Chang WC*, Kwong VWY, Lau ESK, So HC, Wong CSM, Chan GHK, Jim OTT, Hui CLM, Chan SKW, Lee EHM, Chen EYH. Sustainability of treatment effect of a 3-year early intervention programme for first-episode psychosis. British Journal of Psychiatry 2017; 211:37-44.

  7. Chang WC*, Waltz JA, Gold JM, Chan TCW, Chen EYH. Mild reinforcement learning deficits in patients with first-episode psychosis. Schizophrenia Bulletin 2016; 42:1476-1485.

  8. Chang WC*, Chan GHK, Jim OTT, Lau ESK, Hui CLM, Chan SKW, Lee EHM, Chen EYH. Optimal duration of an early intervention programme for first-episode psychosis: randomised controlled trial. British Journal of Psychiatry 2015; 206 (6):492-500

  9. Chang WC*, Hui CLM, Tang JYM, et al. Impacts of duration of untreated psychosis on cognition and negative symptoms in first-episode schizophrenia: a 3-year prospective follow-up study. Psychological Medicine 2013; 43:1883-1894..

  10. Chang WC*, Hui CLM, Tang JYM, et al. Persistent negative symptoms in first-episode schizophrenia: a prospective three-year follow-up study. Schizophrenia Research 2011; 133:22-28.

Full Publication List

Books & Book Chapters

  1. Hui CLM, Chang WC, Chan KW, Lee HME, Suen YN, Chen EYH. International services for assessing and treating psychosis risk. Risk Factors for Psychosis. Elsevier, 2020 383-393.

  2. 陳友凱, 陳喆燁, 張頴宗, 李浩銘, 許麗明 (2014).《思覺失調個案剖析》中華書局(香港)有限公司.

  3. Chang WC, Wong YC. Chapter 11: The diagnostic interview in early psychosis. In: Early Psychosis Intervention: a culturally adaptive clinical guide. Edi by Chen EYH, Lee H, Chan GHK, Wong GHY. Hong Kong University Press 2013.

  4. Lam MML, Lee CC, Chang WC, Hung SF. Chapter 12: Handling at-risk mental state. In: Early Psychosis Intervention: a culturally adaptive clinical guide. Edi by Chen EYH, Lee H, Chan GHK, Wong GHY. Hong Kong University Press 2013.

  5. Chang WC, Chiu CPY. Chapter 28: Handling patients with negative symptoms. In: Early Psychosis Intervention: a culturally adaptive clinical guide. Edi by Chen EYH, Lee H, Chan GHK, Wong GHY. Hong Kong University Press 2013.

Awards

  1. HK RGC Clinical Research Fellowship in 2014 .

  2. Distinguished Young Fellow, HK Academy of Medicine in 2014

  3. IEPA (International Early Psychosis Association) Young Investigator Award in 2016

  4. NARSAD Young Investigator Award, Brain & Behavior Research Foundation, USA in 2016

  5. Faculty Outstanding Research Output Award as one of the co-authors for the publication in 2018 and 2019

Research Grants

External research grants funded as Principal Investigator

  1. Reward learning impairment in clinical high-risk individuals, first-episode psychosis patients and their non-psychotic siblings: psychosis prediction and endophenotypic investigation (RGC General Research Fund in 2014, 3-year project)

  2. A longitudinal multimodal MRI investigation for clinical and functional outcome prediction in individuals at clinical high-risk for psychosis: a prospective 2-year follow-up study (RGC General Research Fund in 2016, 3-year project)

  3. Pathway to care and three-year outcome comparison of extended early intervention service and standard psychiatric care for adults presenting with first-episode psychosis (HMRF: Commissioned Programme on Mental Health Policy & Service in 2016, 2-year project)

  4. Effort-based decision making in patients presenting with first-episode schizophrenia-spectrum disorder: a prospective 1-year follow-up study (NARSAD Young Investigator Grant, Brain & Behavior Research Foundation in 2017, 2-year project)

  5. Glutamatergic abnormalities and prediction of clinical and functional outcomes in individuals at clinical high-risk for psychosis: a 2-year longitudinal proton magnetic spectroscopy study (RGC General Research Fund in 2018, 3-year project)

  6. Probing brain abnormalities for youths with subclinical psychotic symptoms: a population-based multimodal MRI study in Hong Kong (HMRF, Health and Medical Research Fund in 2020, 3-year project)

  7. A longitudinal multimodal neuroimaging and cognitive investigations in first-episode schizophrenia and first-episode bipolar disorder: a prospective 1-year follow-up study (RGC General Research Fund in 2021, 3-year project)

  8. Ambulatory digital phenotyping of negative symptoms and functional outcome in first-episode psychosis: a prospective 6-month follow-up study (RGC General Research Fund in 2022, 2-year project)

  9. Risk prediction models of mortality and complications of Chinese patients with severe mental illness and co-existing diabetes in Hong Kong: a population-based cohort study (HMRF, Health and Medical Research Fund in 2023, 2-year project)

  10. Integrated innovative artificial intelligence, genomic, and biomedical technologies in healthcare: objective diagnosis, personalized therapy, and determining the etiology of major mental disorders (Strategic Theme Grant in 2024, 5-year project, as Co-PI)
     

bottom of page